US 7,501,132 B2
	Multiple antigenic peptides immunogenic against Streptococcus pneumonia
Edwin W. Ades, Atlanta, Ga. (US); Scott E. Johnson, Lilburn, Ga. (US); Danny L. Jue, Tucker, Ga. (US); Jacquelyn S. Sampson, College Park, Ga. (US); and George M. Carlone, Stone Mountain, Ga. (US)
Assigned to The United States of America as represented by the Department of Health and Human Services, Washington, D.C. (US)
Filed on Jun. 06, 2005, as Appl. No. 11/145,814.
Application 11/145814 is a continuation of application No. 09/613092, filed on Jul. 10, 2000, granted, now 6,903,184.
Application 09/613092 is a continuation in part of application No. PCT/US99/04326, filed on Feb. 26, 1999, abandoned.
Claims priority of provisional application 60/076565, filed on Mar. 02, 1998.
Prior Publication US 2005/0226891 A1, Oct. 13, 2005
Int. Cl. A61K 39/09 (2006.01); A61K 39/02 (2006.01); A61K 39/38 (2006.01); A61K 39/385 (2006.01); A61K 38/00 (2006.01); A01N 37/18 (2006.01)

U.S. Cl. 424—244.1  [424/242.1; 424/234.1; 424/190.1; 424/193.1; 424/184.1; 514/2; 530/300; 530/825]

1 Claim

1. A method for conferring protective immunity in a subject against a S. pneumoniae infection, comprising administering to the subject a therapeutic composition comprising an isolated peptide that immunospecifically binds to a monoclonal antibody that immunospecifically binds to Streptococcus pneumoniae pneumococcal surface adhesion A protein (PsaA), wherein the peptide is a multiple antigenic peptide that has at least one first arm comprising the amino acid sequence of SEQ ID NO: 5, at least one second arm comprising the amino acid sequence of SEQ ID NO: 6, and at least one third arm comprising the amino acid sequence of SEQ ID NO: 7, thereby conferring the protective immunity in the subject against the S. pneumoniae infection.