R denotes a group of formula

p denotes the number 1,

o denotes the number 2,

Y¹ denotes the carbon atom,

Y² denotes the nitrogen atom,

R⁵, R⁶ and R⁷ each denote the hydrogen atom,

R^N denotes a N-(aminocarbonyl)-N-phenylamino group or

a mono- or bicyclic heterocycle selected from the group consisting of 1,3-dihydro-4-phenyl-2H-2-oxoimidazol-1-yl,

1,3-dihydro-5-phenyl-2H-2-oxoimidazol-1-yl,

1,3-dihydro-2(2H)-oxobenzimidazol-1-yl,

3,4-dihydro-2(1H)-oxothieno [3,4-d]pyrimidin-3-yl,

1H-benzimidazol-1-yl,

3,4-dihydro-2(1H)-oxoquinazolin-3-yl,

3,4-dihydro-2(1H)-oxoquinazolin-1-yl,

2,3,4,5-tetrahydro-2(1H)-oxo-1,3-benzodiazepin-3-yl,

2(1H)-oxoquinolin-3-yl, or

1,1-dioxido-3(4H)-oxo-1,2,4-benzothiadiazin-2-yl,

wherein said mono- and bicyclic heterocycles optionally are monosubstituted in the carbon skeleton and/or at the phenyl groups contained in these groups by a chlorine atom, or by a methyl, or hydroxy group,

X denotes an oxygen atom or 2 hydrogen atoms,

Z denotes a methylene group or the group —NR¹, wherein

R¹ denotes a hydrogen atom or a methyl group,

R¹¹ denotes a hydrogen atom,

n denotes the number 1 and m denotes the number 0 or

n denotes the number 0 and m denotes the number 1,

R² denotes an aromatic group selected from phenyl, 1-naphthyl and 2-naphthyl, wherein said aromatic group optionally is

mono- or disubstituted by fluorine, chlorine or bromine atoms, by methyl, methoxy, hydroxy or amino groups and the substituents may be identical or different, or trisubstituted by two bromine atoms and either one hydroxy, one amino, one methyl, one methoxy group or

trisubstituted by two chlorine atoms and one hydroxy group or

trisubstituted by two methyl groups and either one hydroxy or one methoxy group,

or R² denotes a 1H-indol-3-yl, 1-methyl-1H-indol-3-yl, 1-(1,1-dimethylethoxycarbonyl)-1H-indol-3-yl, 2-thienyl, 3-thienyl or pyridinyl group,

A denotes the divalent group of formula

 (linked to the group —NR³R⁴ of formula (I) via the carbonyl group)

R⁸ denotes the hydrogen atom or the methyl group and

R⁹ denotes the hydrogen atom or an unbranched C_1-4-alkyl group, which may be substituted in the ω-position by an amino, methylamino, dimethylamino or amino iminomethylamino group,

R³ denotes a hydrogen atom or

a C_1-4-alkyl group optionally substituted in the ω-position by an amino, methylamino or dimethylamino group,

R⁴ denotes a hydrogen atom, a methyl or ethyl group,

or R³ and R⁴ together with the enclosed nitrogen atom denote a group of general formula

Y³ denotes the carbon atom or, if R¹² denotes a free pair of electrons, Y³ denotes a nitrogen atom,

r denotes the number 1,

q denotes the number 1,

R¹⁰ denotes a C_1-3-alkyl group which may be substituted in the ω-position by a dialkylamino group having 1 to 3 carbon atoms in each alkyl moity, or

a phenyl, pyridinyl or diazinyl group, each of which may be substituted in the carbon skeleton by methyl or methoxy group,

a 1-pyrrolidinyl, 1-piperidinyl, 4-(dimethylamino)-1-piperidinyl or 4-piperidinyl group, wherein the nitrogen atom of the 4-piperidinyl group may be substituted by an alkyl group having 1 to 3 carbon atoms,

R¹² denotes a hydrogen atom, or

a free pair of electrons if Y³ denotes a nitrogen atom, and

R¹³ and R¹⁴ each denote a hydrogen atom,

or a tautomer or salt thereof