US 7,498,019 B2
	Delivery of compounds for the treatment of headache through an inhalation route
Ron L. Hale, Woodside, Calif. (US); Joshua D. Rabinowitz, Princeton, N.J. (US); Dennis W. Solas, San Francisco, Calif. (US); and Alejandro C. Zaffaroni, Atherton, Calif. (US)
Assigned to Alexza Pharmaceuticals, Inc., Mountain View, Calif. (US)
Filed on Mar. 21, 2006, as Appl. No. 11/385,992.
Application 11/385992 is a continuation in part of application No. 10/792012, filed on Mar. 03, 2004, granted, now 7,018,621.
Application 10/792012 is a continuation in part of application No. 10/792239, filed on Mar. 03, 2004, granted, now 7,014,840.
Application 10/792239 is a continuation in part of application No. 10/766574, filed on Jan. 27, 2004, granted, now 7,045,118.
Prior Publication US 2006/0233717 A1, Oct. 19, 2006
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/12 (2006.01); A61K 9/14 (2006.01); A61M 15/00 (2006.01)

U.S. Cl. 424—45  [424/46; 424/434; 424/489; 424/499; 514/958; 128/200.14; 128/200.15; 128/200.24]

54 Claims

1. A condensation aerosol for delivery of rizatriptan formed by heating a composition containing rizatriptan coated on a solid support to form a vapor and condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise at least 10 percent by weight of rizatriptan and less than 5 percent by weight of rizatriptan degradation products, and the condensation aerosol has an MMAD of less than 5 microns.