US 7,497,980 B2
Microneedles and microneedle fabrication
Yuan Xu, Singapore (Singapore); Mei Ma Chen, Singapore (Singapore); Zhongli Li, Singapore (Singapore); Chee Yen Lim, Singapore (Singapore); and Pei Ying Joyce Tan, Singapore (Singapore)
Assigned to Agency for Science, Technology and Research, Centros (Singapore)
Appl. No. 10/505,035
PCT Filed Nov. 10, 2003, PCT No. PCT/SG03/00260
§ 371(c)(1), (2), (4) Date Aug. 17, 2004,
PCT Pub. No. WO2005/044364, PCT Pub. Date May 19, 2005.
Prior Publication US 2006/0202385 A1, Sep. 14, 2006
Int. Cl. B29C 33/42 (2006.01)
U.S. Cl. 264—219  [219/69.13] 31 Claims
OG exemplary drawing
 
1. A method of manufacturing a master mould for use in making microneedles, from a block of a first material, the method comprising:
cutting across the block in at least two cutting passes in different directions to provide a master mould comprising a master mould base surface with a plurality of master mould needles protruding therefrom, wherein in each cutting pass at least one surface of each of the plurality of protruding master mould needles are formed;
wherein the master mould needles correspond to the microneedles to be made.