US 7,494,997 B2
Amide derivative
Tetsuo Asaki, Uji (Japan); Taisuke Hamamoto, Matsubara (Japan); and Yukiteru Sugiyama, Yamashina-ku (Japan)
Assigned to Nippon Shinyaku Co., Ltd., Kyoto (Japan)
Appl. No. 10/519,722
PCT Filed Jun. 27, 2003, PCT No. PCT/JP03/08192
§ 371(c)(1), (2), (4) Date Dec. 28, 2004,
PCT Pub. No. WO2004/002963, PCT Pub. Date Jan. 08, 2004.
Claims priority of application No. 2002-189269 (JP), filed on Jun. 28, 2002; application No. 2002-305146 (JP), filed on Oct. 18, 2002; and application No. 2002-377937 (JP), filed on Dec. 26, 2002.
Prior Publication US 2006/0014742 A1, Jan. 19, 2006
Int. Cl. C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61P 35/00 (2006.01)
U.S. Cl. 514—242  [514/272; 514/252.01; 514/252.1; 514/252.12; 514/336; 544/182; 544/238; 544/336; 544/356; 544/358; 546/268.1] 7 Claims
 
1. An amide derivative represented by the following formula [1], or a salt thereof;

OG Complex Work Unit Drawing
R1 represents a saturated cyclic amino group (the saturated cyclic amino group may be substituted by 1 to 3 same or different members selected from the group consisting of alkyl, alkoxycarbonyl, halogen, haloalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino, carbamoyl, monoalkylcarbamoyl and dialkylcarbamoyl), monoalkylamino or dialkylamino;
R2 represents alkyl, halogen, haloalkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyl, amino, monoalkylarmino, dialkylamino, nitro, carbamoyl, monoalkylcarbamoyl, dialkylcarbamoyl or cyano;
R3 represents hydrogen, halogen or alkoxy;
Het1 represents any of groups of the following formulas [2] to [8];

OG Complex Work Unit Drawing
Het2 represents pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or 1, 2-dihydropyridazinyl (the Het2 may be substituted by 1 to 3 same or different members selected from the group consisting of alkyl, halogen and amino);
Excluding compound wherein R1 is (i) pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl, all of which may be substituted by 1 to 3 same or different members selected from the group consisting of alkyl, alkoxycarbonyl, halogen, haloalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino, carbamoyl, monoalkylcarbamoyl and dialkylcarbamoyl, (ii) monoalkylamino, or (iii) dialkylamino, Hetl is a group of the formula [6], and Het2 is pyrazinyl or pyridyl which may be substituted by alkyl.