| US 7,494,804 B2 | ||
| Polynucleotide encoding cytokine receptor zcytor17 multimer | ||
| Cindy A. Sprecher, Sierra Vista, Ariz. (US); Zeren Gao, Redmond, Wash. (US); Joseph L. Kuijper, Kenmore, Wash. (US); Maria M. Dasovich, Seattle, Wash. (US); Francis J. Grant, Seattle, Wash. (US); Scott R. Presnell, Tacoma, Wash. (US); Theodore E. Whitmore, Redmond, Wash. (US); Angela K. Hammond, Maple Valley, Wash. (US); Julia E. Novak, Bainbridge Island, Wash. (US); Jane A. Gross, Seattle, Wash. (US); and Stacey R. Dillon, Seattle, Wash. (US) | ||
| Assigned to ZymoGenetics, Inc., Seattle, Wash. (US) | ||
| Filed on Jan. 21, 2003, as Appl. No. 10/351,157. | ||
| Claims priority of provisional application 60/435361, filed on Dec. 19, 2002. | ||
| Claims priority of provisional application 60/389108, filed on Jun. 14, 2002. | ||
| Claims priority of provisional application 60/350325, filed on Jan. 18, 2002. | ||
| Prior Publication US 2003/0215838 A1, Nov. 20, 2003 | ||
| Int. Cl. C12N 15/12 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); A61K 38/20 (2006.01); C07K 14/47 (2006.01) | ||
| U.S. Cl. 435—320.1 [435/69.1; 435/71.1; 435/471; 435/325; 435/255.1; 536/23.5; 530/351] | 9 Claims |
| 1. An expression vector comprising the following operably linked elements:
a) a first transcription promoter; a first DNA segment encoding a first cytokine receptor polypeptide comprising amino acid
residues 20–732 of SEQ ID NO:111; and a first transcription terminator, and
b) a second transcription promoter; a second DNA segment encoding a second cytokine receptor polypeptide comprising amino
acid residues 28–979 of SEQ ID NO:7; and a second transcription terminator;
wherein the first cytokine receptor polypeptide and the second cytokine receptor polypeptide form a multimeric or heterodimeric
cytokine receptor; and
wherein the multimeric or heterodimeric cytokine receptor binds to a ligand comprising amino acid residues 27–164 of SEQ ID
NO:2.
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