US 7,494,653 B2
	Method and compositions for immunization with the Pseudomonas V antigen
Dara W. Frank, West Allis, Wis. (US); Jeannine Wiener-Kronish, San Francisco, Calif. (US); Timothy L. Yahr, Solon, Iowa (US); Teiji Sawa, San Francisco, Calif. (US); and Robert B. Fritz, Milwaukee, Wis. (US)
Assigned to MCW Research Foundation, Inc., Milwaukee, Wis. (US); and The Regents of the University of California, Oakland, Calif. (US)
Appl. No. 10/496,059 PCT Filed Jan. 25, 2002, PCT No. PCT/US02/02382 § 371(c)(1), (2), (4) Date Nov. 03, 2004, PCT Pub. No. WO02/064161, PCT Pub. Date Aug. 22, 2002.
Prior Publication US 2005/0063985 A1, Mar. 24, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/40 (2006.01)

U.S. Cl. 424—170.1  [424/130.1; 424/139.1; 424/150.1; 424/164.1; 530/387.1; 530/388.1]

22 Claims

1. An isolated monoclonal antibody that specifically binds to Pseudomonas aeruginosa PcrV antigen, wherein the antibody comprises a heavy chain (SEQ. ID NO: 2) and a light chain (SEQ. ID NO: 4) wherein the antibody or a fragment thereof specifically binds to an epitope that includes amino acid residues 144 through 257 of SEQ ID NO: 7 in Pseudomonas aeruginosa PcrV antigen.