| US 7,494,622 B2 | ||
| Device for measuring the electrical activity of biological elements and its applications | ||
| Nathalie Picollet-Dahan, La Ferriere (France); Patrice Caillat, Echirolles (France); Frederic Revol-Cavalier, Seyssins (France); Francois Chatelain, Voreppe (France); and Fabien Sauter, Seyssinet-Pariset (France) | ||
| Assigned to Commissariat a l'Energie Atomique, Paris (France) | ||
| Appl. No. 10/522,599 PCT Filed Aug. 28, 2003, PCT No. PCT/EP03/15044 § 371(c)(1), (2), (4) Date Jan. 26, 2005, PCT Pub. No. WO2004/038409, PCT Pub. Date May 06, 2004. |
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| Claims priority of application No. 02 10663 (FR), filed on Aug. 28, 2002. | ||
| Prior Publication US 2006/0163063 A1, Jul. 27, 2006 | ||
| Int. Cl. G01N 27/00 (2006.01) | ||
| U.S. Cl. 422—82.01 [422/82.02; 422/102; 324/691; 324/692] | 31 Claims |
| 1. A device for measuring electrical activity of at least one biological element, comprising:
a substantially plane substrate, which has a lower face and an upper face and which has at least one through opening for housing
the biological element, said opening being delimited by a set of walls;
two substantially plane plates placed on either side of the lower and upper faces of the substrate and that delimit with the
set of walls a chamber that is filled, when the device is being used, with a liquid medium;
wherein each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening
in the substrate;
wherein each of the plates further has at least one channel that starts inside the chamber and connects the chamber to outside
of the device; and
wherein the chamber communicates with the outside of the device only through the channels.
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