	US 7,332,477 B2
	Photocleavable DNA transfer agent
J. Kevin Cammack, Oceanside, Calif. (US); Sang Van, San Diego, Calif. (US); and Peng Wang, Vista, Calif. (US)
Assigned to Nitto Denko Corporation, Osaka (Japan)
Filed on Jul. 02, 2004, as Appl. No. 10/884,530.
Claims priority of provisional application 60/486390, filed on Jul. 10, 2003.
Prior Publication US 2005/0037401 A1, Feb. 17, 2005
Int. Cl. A61K 48/00 (2006.01); A61K 31/74 (2006.01); A61K 38/00 (2006.01); A61K 38/02 (2006.01); G03C 1/52 (2006.01); G03C 1/30 (2006.01); C12N 15/63 (2006.01); A01N 43/66 (2006.01); C08F 2/46 (2006.01); C08F 2/50 (2006.01); C08J 3/28 (2006.01); C07D 413/00 (2006.01); C07H 19/12 (2006.01); C07C 245/00 (2006.01); C09B 67/00 (2006.01)

U.S. Cl. 514—44 [424/78.18; 430/157; 430/175; 430/626; 435/320.1; 514/246; 522/6; 522/32; 530/300; 536/23.1; 536/28.3; 544/83; 544/113; 534/558; 8/550]

22 Claims

1. A photocleavable DNA transfer composition comprising:

a) an acid sensitive polymer comprising a repeat unit selected from the group consisting of (3-ethoxy-2-{1-[2-(2-isopropoxy-ethoxy)-ethoxy]-ethoxymethyl}-2- methyl-propionic acid amide) and (3-ethoxy-2-{1-[2-(2-isopropoxy-ethoxy)-ethoxy]-ethoxymethyl}-2-methyl-propionic acid ester);

b) a photoacid generator; and

c) a bioactive agent, wherein the bioactive agent is a polynucleotide.