| US 7,493,225 B2 | ||
| Method for calibrating mass spectrometry (MS) and other instrument systems and for processing MS and other data | ||
| Yongdong Wang, Wilton, Conn. (US); and Ming Gu, Yardley, Pa. (US) | ||
| Assigned to Cerno Bioscience LLC, Danbury, Conn. (US) | ||
| Appl. No. 10/576,564 PCT Filed Oct. 20, 2004, PCT No. PCT/US2004/034618 § 371(c)(1), (2), (4) Date Apr. 18, 2006, PCT Pub. No. WO2005/040985, PCT Pub. Date May 06, 2005. |
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| Application 10/576564 is a continuation in part of application No. 10/689313, filed on Oct. 20, 2003, granted, now 6,983,213. | ||
| Prior Publication US 2007/0136017 A1, Jun. 14, 2007 | ||
| Int. Cl. G01R 35/00 (2006.01) | ||
| U.S. Cl. 702—85 [250/282; 250/287; 436/58; 702/23; 702/27; 702/104; 702/109; 702/189] | 34 Claims |
| 1. A method for obtaining at least one calibration filter for a Mass Spectrometry (MS) instrument system, comprising the steps
of:
obtaining, for a given calibration ion with its isotopes, measured isotope peak cluster data in a mass spectral range;
calculating, for the given calibration ion with its isotopes, relative isotope abundances and actual mass locations of isotopes
corresponding thereto;
specifying mass spectral target peak shape functions;
performing convolution operations between the calculated relative isotope abundances and the mass spectral target peak shape
functions to form calculated isotope peak cluster data; and
performing a deconvolution operation between the measured isotope peak cluster data and the calculated isotope peak cluster
data after the convolution operations to obtain the at least one calibration filter.
|