| US 7,491,803 B2 | ||
| Human anti-human interleukin-18 antibody, fragment thereof and method for using same | ||
| Kazuhisa Sugimura, Kagoshima (Japan); Kenji Nakanishi, Nara (Japan); and Toshihiro Nakashima, Kumamoto (Japan) | ||
| Assigned to Japan Science & Technology Agency, Kawaguchi (Japan); and Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto-Shi (Japan) | ||
| Appl. No. 10/555,074 PCT Filed Apr. 30, 2004, PCT No. PCT/JP2004/006403 § 371(c)(1), (2), (4) Date Oct. 28, 2005, PCT Pub. No. WO2004/097019, PCT Pub. Date Nov. 11, 2004. |
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| Prior Publication US 2006/0292145 A1, Dec. 28, 2006 | ||
| Int. Cl. C07K 16/00 (2006.01); C12N 15/09 (2006.01) | ||
| U.S. Cl. 530—388.15 [435/69.1; 435/320.1; 435/325; 435/7.1; 536/23.5] | 28 Claims |
| 1. An isolated human antibody, comprising
human immunoglobulin VH-chain CDR1, CDR2, and CDR3 of a polypeptide consisting of amino-acid sequences represented by SEQ
ID NOS: 4, 5, and 6, respectively; and
human immunoglobulin VL-chain CDR1, CDR2, and CDR3 of a polypeptide consisting of amino-acid sequences represented by SEQ
ID NOS: 10, 11, and 12, respectively.
|