| US 7,491,743 B2 | ||
| Inhibitors of cellular necrosis | ||
| Gregory D. Cuny, Somerville, Mass. (US); Junying Yuan, Newton, Mass. (US); Prakash Jagtap, Beverly, Mass. (US); and Alexei Degterev, Brookline, Mass. (US) | ||
| Assigned to President and Fellows of Harvard College, Cambridge, Mass. (US); and The Brigham and Women's Hospital, Inc., Boston, Mass. (US) | ||
| Filed on Aug. 30, 2004, as Appl. No. 10/930,690. | ||
| Claims priority of provisional application 60/498882, filed on Aug. 29, 2003. | ||
| Prior Publication US 2005/0119260 A1, Jun. 02, 2005 | ||
| Int. Cl. A61K 31/415 (2006.01); C07D 403/02 (2006.01) | ||
| U.S. Cl. 514—397 [514/398; 548/312.1] | 25 Claims |
1. A compound of the formula:
 a stereoisomeric form thereof, or a pharmaceutically acceptable acid or base addition salt of the compound or of a stereoisomeric
form thereof; wherein
Y represents NR8;
G represents NR7;
R1, R2, and R3 represent independently H, OH, OR8, F, Cl, Br, I, N(R8)2, COOH, CO2R8, NO2, NHC(O)R8, lower alkyl, substituted lower alkyl, or aryl;
R4 represents independently OH, OR8, F, Cl, Br, I, N(R8)2, COOH, CO2R8, NO2, NHC(O)R8, methyl, methoxyl, lower alkyl, substituted lower alkyl, aryl, or amine;
R5 and R7 represent independently H or lower alkyl;
R6 represents lower alkyl; each R8 represents independently H, lower alkyl, substituted lower alkyl, aryl, substituted aryl, arylalkyl, alkenyl, or alkynyl;
R9, R10, R9′, and R10′ represent independently H, F, Cl, Br, I, lower alkyl, or substituted lower alkyl, or a three to six membered cycloalkyl
that includes Cn and/or Cn′; and
n and n′ equals an integer from zero to five.
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