| US 7,491,729 B2 | ||
| 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof | ||
| Margaretha Bakker, Seeheim-Jugenheim (Germany); Wilfried Hornberger, Neustadt (Germany); Andreas Kling, Mannheim (Germany); Udo Lange, Mannheim (Germany); Helmut Mack, Ludwigshafen (Germany); Achim Moeller, Grundstadt (Germany); Reinhold Mueller, Schifferstadt (Germany); Kurt Schellhaas, Ludwigshafen (Germany); Martin Schmidt, Bensheim (Germany); Gerd Steiner, Kircheim (Germany); and Karsten Wicke, Altrip (Germany) | ||
| Assigned to Abbott GmbH & Co. KG, Wiesbaden (Germany) | ||
| Appl. No. 10/539,708 PCT Filed Dec. 17, 2003, PCT No. PCT/EP03/14423 § 371(c)(1), (2), (4) Date Dec. 30, 2005, PCT Pub. No. WO2004/055024, PCT Pub. Date Jul. 01, 2004. |
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| Claims priority of application No. 102 59 382 (DE), filed on Dec. 18, 2002. | ||
| Prior Publication US 2006/0142317 A1, Jun. 29, 2006 | ||
| Int. Cl. A01N 43/54 (2006.01); A61K 31/505 (2006.01); C07D 239/00 (2006.01); C07D 471/00 (2006.01); C07D 487/00 (2006.01); C07D 491/00 (2006.01) | ||
| U.S. Cl. 514—267 [544/250] | 18 Claims |
1. A compound of the formula (I)
 A is O, S, SO, NR5 or CH2;
R5 is H, C1-5-alkyl, aryl, aralkyl, acyl or alkoxycarbonyl;
R4 is H or methyl;
n is 1 or 2;
m is 1 or 2;
R1 is C1-8-alkylene;
R2 is a group of the formula
 R3 is 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, optionally, the
fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and
heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6); and the radicals
R6 are independently of one another C1-5-alkyl, and physiologically tolerated salts thereof.
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