| US 7,491,728 B2 | ||
| Pyrimidinone compounds as calcilytics | ||
| Irina V. Shcherbakova, Salt Lake City, Utah (US); Manuel F. Balanddrin, Salt Lake City, Utah (US); Guangfei Huang, Alchua, Fla. (US); Otto Geoffroy, Alchua, Fla. (US); John Fox, Salt Lake City, Utah (US); Robert Marquis, King of Prussia, Pa. (US); Dennis Shinji Yamashita, King of Prussia, Pa. (US); Juan Luengo, King of Prussia, Pa. (US); and Wenyong Wang, King of Prussia, Pa. (US) | ||
| Assigned to SmithKline Beecham Corp., Philadelphia, Pa. (US) | ||
| Appl. No. 10/552,363 PCT Filed Apr. 07, 2004, PCT No. PCT/US2004/010638 § 371(c)(1), (2), (4) Date Nov. 20, 2006, PCT Pub. No. WO2004/092120, PCT Pub. Date Oct. 28, 2004. |
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| Prior Publication US 2007/0197555 A1, Aug. 23, 2007 | ||
| Int. Cl. A61K 31/517 (2006.01); A61K 31/50 (2006.01); C07D 403/14 (2006.01); C07D 239/30 (2006.01); C07D 239/46 (2006.01); A61P 35/00 (2006.01) | ||
| U.S. Cl. 514—266.21 [514/269; 514/258.1; 514/266.31; 544/284; 544/289; 544/298; 544/253] | 16 Claims |
1. A compound having the chemical formula:
 R1 and R2 are independently H, halogen, CN, CF3, lower alkyl, cycloalk, or aryl; or R1 and R2 are together —(CH2)n— and n is 5, 4, or 3;
R3 is aryl, which is optionally substituted by 1 to 4 substitutents on the aryl and each substitutent independently is H, halogen,
CN, CF3, OCF3, lower alkyl, N(lower alkyl)2, lower alkoxy, OH, OC(O)-lower alkyl, OC(O)-lower alkylamino or OC(O)-lower alkyl-N(lower alkyl)2; and
R4 is —(CH2)n—R5 wherein n is 2, and R5 is aryl, which is optionally substituted by 1 to 3 substitutents on the aryl and each substitutent is independently H, halogen,
lower alkyl or lower alkoxy;
or a pharmaceutically acceptable salt thereof.
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