| US 7,491,723 B2 | ||
| Alkanol and cycloalkanol-amine derivatives and methods of their use | ||
| Eugene John Trybulski, Huntingdon Valley, Pa. (US); Paige Erin Mahaney, Pottstown, Pa. (US); Lori Krim Gavrin, Philadelphia, Pa. (US); William Jay Moore, Collegeville, Pa. (US); and Joseph Peter Sabatucci, Collegeville, Pa. (US) | ||
| Assigned to Wyeth, Madison, N.J. (US) | ||
| Filed on Oct. 12, 2004, as Appl. No. 10/962,880. | ||
| Claims priority of provisional application 60/510942, filed on Oct. 14, 2003. | ||
| Claims priority of provisional application 60/561422, filed on Apr. 12, 2004. | ||
| Claims priority of provisional application 60/569884, filed on May 11, 2004. | ||
| Prior Publication US 2005/0171115 A1, Aug. 04, 2005 | ||
| Int. Cl. A61K 31/497 (2006.01); C07D 401/00 (2006.01); C07D 403/00 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 411/00 (2006.01); C07D 413/00 (2006.01); C07D 417/00 (2006.01); C07D 419/00 (2006.01); C07D 241/04 (2006.01); C07D 295/00 (2006.01) | ||
| U.S. Cl. 514—252.12 [544/360; 544/373; 544/374; 544/379; 544/391; 544/397; 544/403; 544/405] | 10 Claims |
1. A compound of formula I;
 W is OR9;
R1 and R2 are, independently, H, OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, or together form, methylenedioxy;
R5 is H or (C1-C6)alkyl;
R6 and R7 are, independently, (C1-C6)alkyl or (C3-C6)cycloalkyl;
R8 is H or (C1-C6)alkyl;
R9 is H, (C1-C4)alkyl, or (C1-C4)alkyl-C(═O);
t is 1, 2, or 3;
and x is 1.
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