| US 7,491,501 B2 | ||
| Methods for identifying modulators of intracellular aggregate formation | ||
| Marie W. Wooten, Auburn, Ala. (US) | ||
| Assigned to Auburn University, Auburn, Ala. (US) | ||
| Filed on Nov. 17, 2004, as Appl. No. 10/991,197. | ||
| Claims priority of provisional application 60/520835, filed on Nov. 17, 2003. | ||
| Prior Publication US 2005/0130896 A1, Jun. 16, 2005 | ||
| Int. Cl. G01N 33/566 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01); A61K 49/00 (2006.01) | ||
| U.S. Cl. 435—7.21 [435/7.8] | 11 Claims |
| 1. A method for identifying a modulator of intracellular aggregate formation comprising:
(a) determining binding of TRAF6 to p62 or a fragment thereof comprising amino acids 225-251 of SEQ ID NO: 1 in the presence
of a test compound;
(b) selecting the test compound that reduces or inhibits TRAF6 binding to p62 and reduces or inhibits intracellular aggregate
formation.
|