| 1. An in vitro method of increasing reaction selectivity among a plurality of reactants in a nucleic acid-templated synthesis
to produce, without the assistance of a ribosome, a reaction product that is not a nucleic acid, the method comprising the
steps of:
(a) providing (i) a template associated with a capturable moiety and comprising a first reactive unit associated with a first
oligonucleotide comprising a predetermined codon sequence, (ii) a first transfer unit comprising a second reactive unit associated
with a second oligonucleotide comprising an anti-codon sequence capable of annealing to said codon sequence, and (iii) a second
transfer unit comprising a third reactive unit different from said second reactive unit associated with a third oligonucleotide
without an anti-codon sequence capable of annealing to said codon sequence, wherein said second reactive unit and said third
reactive unit are capable of reacting independently with said first reactive unit and said second reactive unit and said third
reactive unit are capable of reacting with one another; and
(b) mixing said template, said first transfer unit and said second transfer unit under conditions to permit annealing of said
second oligonucleotide of said first transfer unit to said first oligonucleotide of said template thereby to enhance covalent
bond formation between said second reactive unit and said first reactive unit to produce the reaction product relative to
covalent bond formation between said third reactive unit and said first reactive unit.
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