| US 7,491,312 B2 | ||
| Identifying therapeutic compounds based on their physical-chemical properties | ||
| Sylvain Gilat, San Francisco, Calif. (US); Gary Binyamin, Palo Alto, Calif. (US); and Guy Miller, San Jose, Calif. (US) | ||
| Assigned to Edison Pharmaceuticals, Inc., San Jose, Calif. (US) | ||
| Filed on Oct. 29, 2003, as Appl. No. 10/696,752. | ||
| Claims priority of provisional application 60/487734, filed on Jul. 16, 2003. | ||
| Claims priority of provisional application 60/422727, filed on Oct. 30, 2002. | ||
| Prior Publication US 2004/0105817 A1, Jun. 03, 2004 | ||
| Int. Cl. G01N 27/26 (2006.01) | ||
| U.S. Cl. 205—787 [435/4; 424/9.2] | 30 Claims |
| 1. A method of identifying and selecting therapeutic compounds having a predetermined core structure, said method comprising:
establishing a relationship between physical-chemical profile and biological activity; wherein the physical-chemical profile
comprises one or more parameters selected from reversibility of one or more oxidation waves or reversibility of one or more
reduction waves; and wherein the biological activity is measured in an assay effective in detecting compounds for the treatment
of a targeted disorder;
testing further potential therapeutic candidates with said core structure for their physical-chemical properties; and
selecting therapeutic compounds based on their physical-chemical parameters falling within a range predefined by the physical-chemical/biological
relationship of the previously tested subset of compounds.
|