US 7,488,865 B2
	Urocortin-deficient mice and uses thereof
Kuo-Fen Lee, Del Mar, Calif. (US); Wylie Vale, La Jolla, Calif. (US); Chien Li, San Diego, Calif. (US); Lingyun Zhao, San Diego, Calif. (US); and Douglas E. Vetter, Boston, Mass. (US)
Assigned to Research Development Foundation, Carson City, Nev. (US)
Filed on May 19, 2003, as Appl. No. 10/440,636.
Claims priority of provisional application 60/381936, filed on May 20, 2002.
Prior Publication US 2004/0055028 A1, Mar. 18, 2004
Int. Cl. A01K 67/00 (2006.01); A01K 67/027 (2006.01); A01K 67/033 (2006.01)

U.S. Cl. 800—18  [800/13]

4 Claims

1. A transgenic mouse whose genome comprises a homozygous disruption of the urocortin gene such that said mouse does not express urocortin protein, wherein said mouse exhibits increased anxiety-like behavior and impaired auditory function compared to a wild-type mouse.