X is CH₂ and Y is NR₁R₂, OCONR₁R₂; or X is C(O) and Y is NR₁R₂; in which R₁ is alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl; R₂ is H, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl, or R₁, R₂, and N to which they are attached, taken together, form a saturated or unsaturated 3-8 membered ring, optionally substituted with R₁′, OR₂′, NR₂′R₃′, SR₂′, C(O)R₂′, CO₂R₂′, or C(O)NR₂′R₃′, R₁′ being alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl, and each of R₂′ and R₃′, independently, being H, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl; and

Z is a bond;