	US 7,488,825 B2
	Method for preparing polymorphism of irinotecan hydrochloride
Hideaki Shimizu, Tokyo (Japan); Atsuhiro Abe, Tokyo (Japan); Takashi Yaegashi, Tokyo (Japan); and Seigo Sawada, Tokyo (Japan)
Assigned to Kabushiki Kaisha Yakult Honsha, Tokyo (Japan)
Appl. No. 10/546,687 PCT Filed Feb. 24, 2004, PCT No. PCT/JP2004/002126 § 371(c)(1), (2), (4) Date Jun. 19, 2006, PCT Pub. No. WO2004/076460, PCT Pub. Date Sep. 10, 2004.
Claims priority of application No. 2003-046908 (JP), filed on Feb. 25, 2003.
Prior Publication US 2006/0234904 A1, Oct. 19, 2006
Int. Cl. C07D 491/22 (2006.01)

U.S. Cl. 546—48 [546/42]

3 Claims

1. A method for preparing c-type crystals of irinotecan hydrochloride, comprising:

mixing irinotecan with one or more solvents selected from the group consisting of acetone, acetonitrile and tetrahydrofuran;

adding hydrochloric acid to the mixture to form crystals; and

collecting the formed crystals;

wherein the crystals have diffraction peaks (2θ) at 9.15°, 10.00°, 11.80°, 12.20°, 13.00° and 13.40° in powder X-ray diffractometry.