US 7,488,476 B2
B-cell epitope peptides of HSP 65, DNA encoding said peptides, antibodies directed against said peptides and the different uses thereof in the treatment of inflammatory and autoimmune diseases
Yaakov Naparstek, Jerusalem (Israel); Rina Ulmansky, Mevaseret Zion (Israel); and Yechezkel Kashi, Haifa (Israel)
Assigned to Hadasit Medical Research Services & Development Ltd., Jerusalem (Israel)
Filed on Aug. 31, 2004, as Appl. No. 10/931,944.
Application 10/931944 is a continuation in part of application No. 10/853567, filed on May 24, 2004, granted, now 7,247,305.
Application 10/853567 is a continuation of application No. 09/847637, filed on May 02, 2001, granted, now 6,770,281.
Application 09/847637 is a continuation in part of application No. PCT/IL99/00595, filed on Nov. 04, 1999.
Claims priority of provisional application 60/107213, filed on Nov. 05, 1998.
Prior Publication US 2005/0123535 A1, Jun. 09, 2005
Int. Cl. A61K 39/395 (2006.01)
U.S. Cl. 424—139.1  [424/130.1; 424/133.1; 424/141.1; 424/150.1] 13 Claims
 
1. A purified antibody directed against a purified peptide consisting of the amino acid sequence of SEQ ID: No. 1 or against biologically functional homologues and derivatives thereof, wherein the biologically functional homologues and derivatives thereof is selected from the group consisting of SEQ ID: No. 2 and SEQ ID: No. 3.