| US RE40,632 E1 | ||
| Mass spectrometer system including a double ion guide interface and method of operation | ||
| Keqi Tang, Richland, Wash. (US); Jean-Jacques Dunyach, San Jose, Calif. (US); and Alan E. Schoen, Saratoga, Calif. (US) | ||
| Assigned to Thermo Finnigan LLC., San Jose, Calif. (US) | ||
| Filed on Mar. 04, 2005, as Appl. No. 11/73,394. | ||
| Application 09/715815 is a continuation in part of application No. 09/454273, filed on Dec. 03, 1999, abandoned. | ||
| Application 11/073394 is a reissue of application No. 09/715815, filed on Nov. 16, 2000, now 6,528,784, filed on Mar. 04, 2003. | ||
| Int. Cl. B01D 59/44 (2006.01); H01J 49/00 (2006.01) | ||
| U.S. Cl. 250—282 [250/281; 250/288] | 42 Claims |
| [ 10. A mass spectrometer system, comprising:
an ion source for creating sample ions at atmospheric pressure from a sample which is in association with a solvent;
a mass analyzer, disposed in a high vacuum mass analyzer chamber, for analyzing said sample ions;
two consecutive multipole ion guides disposed between said ion source and said high vacuum mass analyzer chamber for directing
ions from said ion source to said high vacuum mass analyzer chamber, said multipole ion guides maintained at a pressure below
atmospheric but higher than the pressure of said high vacuum mass analyzer chamber; and
at least one of said multipole ion guides having means associated therewith for defining the translational kinetic energy
of ions directed therethrough, and wherein said translational kinetic energy is chosen so that solvent adduct species formed
in high pressure regions of the system are converted within said multipole ion guides to sample ions by collision-induced dissociation without fragmentation of sample ions before entering said high vacuum mass analyzer chamber.]
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