| US 7,485,742 B2 | ||
| Non-glycosidic and non-peptidic inhibitors of selectin, and the use thereof | ||
| Gerd Dannhardt, Mainz (Germany); Holger Ulbrich, Mainz (Germany); Philip Prech, Mainz (Germany); and Andreas Luxenburger, Saarlouis (Germany) | ||
| Assigned to Johannes Gutenberg-Universität Mainz, Mainz (Germany) | ||
| Appl. No. 11/572,214 PCT Filed Jul. 26, 2005, PCT No. PCT/EP2005/008125 § 371(c)(1), (2), (4) Date Jul. 06, 2007, PCT Pub. No. WO2006/010598, PCT Pub. Date Feb. 02, 2006. |
||
| Claims priority of application No. 10 2004 036 213 (DE), filed on Jul. 26, 2004. | ||
| Prior Publication US 2007/0276036 A1, Nov. 29, 2007 | ||
| Int. Cl. C07C 205/00 (2006.01); C07C 229/00 (2006.01); C07C 249/00 (2006.01) | ||
| U.S. Cl. 560—45 [560/21; 560/43; 560/44; 562/433; 562/440; 562/442; 562/443; 562/453] | 15 Claims |
1. A compound having the general formula 1
 wherein
n is 0 or 1,
R1 to R6 independently are H, COOH, COOCH3, COOC2H5 or halogen, and
X is C═N—O—(CH2)m—Y or N—C(═O)—(CH2)m—Y,
wherein
m is 5 or 6, and
Y is
 wherein
R7 is H or O(CH2)9CH3,
or a derivative, diastereomer, or pharmaceutically acceptable salt thereof.
|