| US 7,485,294 B2 | ||
| Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof | ||
| Sandrine Bourgeois, Paris (France); Elias Fattal, Paris (France); Antoine Andremont, Paris (France); and Patrick Couvreur, Villebon-sur-Yvette (France) | ||
| Assigned to Da Volterra, (France) | ||
| Appl. No. 10/524,318 PCT Filed Aug. 06, 2003, PCT No. PCT/FR03/02474 § 371(c)(1), (2), (4) Date Feb. 09, 2005, PCT Pub. No. WO2004/016248, PCT Pub. Date Feb. 26, 2004. |
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| Claims priority of application No. 02 10151 (FR), filed on Aug. 09, 2002; and application No. 02 13514 (FR), filed on Oct. 29, 2002. | ||
| Prior Publication US 2005/0249716 A1, Nov. 10, 2005 | ||
| Int. Cl. C12N 9/00 (2006.01); C12N 9/14 (2006.01); C12N 9/18 (2006.01); A61K 38/43 (2006.01); A61K 38/46 (2006.01); A01N 63/00 (2006.01) | ||
| U.S. Cl. 424—94.1 [424/94.6; 424/93.1; 435/183; 435/195; 435/197] | 14 Claims |
| 1. A drug delivery composition for oral administration, and colonic release, of an active agent, the composition comprising:
a) an active agent capable of inactivating an antibiotic, wherein the active agent is an isolated enzyme capable of inactivating
a β-lactam, macrolide, or quinolone antibiotic; and
b) a pectinate suitable for administering the active agent to the colon, wherein said pectinate comprises a cationic pectinate salt in the form of a pectin bead which encloses the active agent.
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