US 7,482,472 B2
Substituted isoindoles and their use
Alexander Straub, Wuppertal (Germany); Thomas Lampe, Dusseldorf (Germany); Jens Pohlmann, Wuppertal (Germany); Susanne Rohrig, Essen (Germany); Elisabeth Perzborn, Wuppertal (Germany); and Karl-Heinz Schlemmer, Wuppertal (Germany)
Assigned to Bayer Healthcare AG, Leverkusen (Germany)
Filed on Mar. 12, 2007, as Appl. No. 11/717,414.
Application 11/717414 is a division of application No. 10/485412, granted, now 7,189,738, previously published as PCT/EP02/07957, filed on Jul. 17, 2002.
Prior Publication US 2008/0039446 A1, Feb. 14, 2008
Int. Cl. C07D 209/44 (2006.01); C07D 207/00 (2006.01); C07D 409/00 (2006.01); A61K 31/33 (2006.01); A61K 31/40 (2006.01); A61K 31/38 (2006.01)
U.S. Cl. 548—470  [548/400; 548/416; 548/452; 548/469; 549/29; 549/59; 514/183; 514/359; 514/408; 514/410; 514/412; 514/414; 514/415; 514/416; 514/430; 514/438] 11 Claims
 
1. A compound of the formula (I)

OG Complex Work Unit Drawing
in which
R1 and R2 together represent O and
R3 and R4 together represent O,
or
R1 represents hydrogen, hydroxy or (C1-C4)-alkoxy,
R2 represents hydrogen and
R3 and R4 together represent O,
or
R1 and R2 together represent O,
R3 represents hydrogen, hydroxy or (C1-C4)-alkoxy and
R4 represents hydrogen,
R5 represents halogen, trifluoromethyl or methyl,
A represents (C1-C4)-alkanediyl which may be substituted by hydroxy or (C1 -C4)-alkoxy,
a represents 0 or 1,
B represents a group

OG Complex Work Unit Drawing
in which
R6 represents hydrogen or (C1-C4)-alkyl,
b represents 0 or 1,
D represents piperazine,
which may be mono- or disubstituted, independently of one another, by hydroxy, carbamoyl, (C1-C4)-alkanoyl, (C3-C7)-cycloalkanoyl, (C3-C7)-cycloalkyl, 5- to 10-membered heterocyclyl, (C1-C4)-alkoxycarbonyl, (C1-C6)-alkyl,
which for its part may be substituted by hydroxy, cyano, (C1-C4)-alkoxy, mono- or di-(C1-C6)-alkylamino, mono- or di-(C1-C6)-alkylaminocarbonyl, 5- to 10-membered heterocyclyl, 5- or 6-membered heterocyclylcarbonyl or 5- to 10-membered heteroaryl, (C6-C10 )-aryl,
which for its part may be substituted by halogen, trifluoromethyl, nitro, (C1-C4)-alkyl or (C1-C4)-alkoxy,
5- to 10-membered heteroaryl,
which for its part may be substituted by cyano, amino or (C1-C4)-alkyl, or 5- to 10-membered heteroarylcarbonyl,
or a salt thereof.