| US 7,482,452 B2 | ||
| Process for preparing 3-aminothienopyridone derivatives | ||
| Graham Robert Evans, Newmarket (United Kingdom); Ian Harold Smith, Kings Langley (United Kingdom); Neil Tremayne, Cambridge (United Kingdom); Leighton Jones, Cambridge (United Kingdom); and Marianne Langston, Cambridge, Mass. (US) | ||
| Assigned to Celltech R&D Limited, Slough (United Kingdom) | ||
| Appl. No. 10/561,051 PCT Filed Jun. 18, 2004, PCT No. PCT/GB2004/002680 § 371(c)(1), (2), (4) Date Jun. 08, 2006, PCT Pub. No. WO2004/113349, PCT Pub. Date Dec. 29, 2004. |
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| Claims priority of application No. 0314493.8 (GB), filed on Jun. 20, 2003; and application No. 0329471.7 (GB), filed on Dec. 19, 2003. | ||
| Prior Publication US 2007/0191608 A1, Aug. 16, 2007 | ||
| Int. Cl. C07D 471/02 (2006.01); C07D 491/02 (2006.01); C07D 498/02 (2006.01); C07D 513/02 (2006.01); C07D 515/02 (2006.01) | ||
| U.S. Cl. 546—114 | 21 Claims |
1. A compound of formula (2):
 wherein R is a —CN, —NO2, —CO2Alk2, —COC1-6alkyl or —CONHet2 group;
Alk2 is an optionally substituted alkyl, arylalkyl, aryl, aryloxyalkyl, alkanoyloxyalkyl or aroyloxyalkyl group;
NHet2 is an optionally substituted 4- to 6-membered heterocycloalkyl group attached through a nitrogen atom to the group —CO;
R1 is an optionally substituted aryl, heteroaryl, cycloalkyl or heterocycloalkyl group; and
each Ry, which may be the same or different, is each a hydrogen atom or a hydrogen atom precursor;
or a salt, protected derivative, or N-oxide thereof.
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