| US 7,482,358 B2 | ||
| Imidazoline compounds | ||
| Nagaaki Sato, Tsukuba (Japan); Osamu Okamoto, Tsukuba (Japan); Makoto Jitsuoka, Tsukuba (Japan); Keita Nagai, Tsukuba (Japan); Akio Kanatani, Tsukuba (Japan); Akane Ishihara, Tsukuba (Japan); Yasuyuki Ishii, Tsukuba (Japan); and Takehiro Fukami, Tsukuba (Japan) | ||
| Assigned to Banyu Pharmaceutical Co., Ltd., Tokyo (Japan) | ||
| Filed on Feb. 07, 2006, as Appl. No. 11/348,459. | ||
| Application 11/348459 is a division of application No. 10/204267, granted, now 7,064,142, previously published as PCT/JP01/01312, filed on Feb. 22, 2001. | ||
| Claims priority of application No. 2000/45042 (JP), filed on Feb. 22, 2000. | ||
| Prior Publication US 2006/0135559 A1, Jun. 22, 2006 | ||
| Int. Cl. A61K 31/435 (2006.01); C07D 401/00 (2006.01) | ||
| U.S. Cl. 514—277 [546/272.7] | 15 Claims |
1. A compound represented by the general formula (I):
 wherein Ar1 represents pyridyl which may be substituted, the substituent being selected from the group consisting of halogen atom, lower
alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, lower alkoxy, halo(lower)alkoxy and lower alkanoyl;
Ar2 represents pyridyl which may be substituted, the substituent being selected from the group consisting of cyano, halogen atom,
nitro, lower alkyl, halo(lower)alkyl, hydroxy, lower alkoxy, halo(lower)alkoxy, formyl, lower alkanoyl, lower alkoxycarbonyl
and lower alkysulfonyl;
Ar3 represents phenyl, naphthyl, thienyl, pyridyl, quinolyl or 1,5-naphthyridinyl which may be substituted, the substituent being
selected from the group consisting of halogen atom, lower alkyl, hydroxy(lower)alkyl, lower alkenyl, di-lower alkylamino,
lower alkoxy, halo(lower)alkoxy, lower alkanoyl and aryl;
R1 represents a group represented by the formula of —Ar3;
R2 and R3 represent independently hydrogen atom, cyclo(lower)alkyl, lower alkenyl or lower alkyl which may be substituted, the substituent
being selected from the group consisting of halogen atom, lower alkylamino, di-lower alkylamino, lower alkanoylamino, hydroxy,
lower alkoxy, formyl, lower alkoxycarbonyl, lower alkylcarbamoyl and di-lower alkylcarbamoyl;
a salt or ester thereof.
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