| US 7,482,008 B1 | ||
| Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor | ||
| Malcolm L. Gefter, Lincoln, Mass. (US); Richard D. Garman, Arlington, Mass. (US); Julia L. Greenstein, West Newton, Mass. (US); Mei-chang Kuo, Winchester, Mass. (US); Bruce L. Rogers, Belmont, Mass. (US); Irwin J. Griffith, North Reading, Mass. (US); Jay P. Morgenstern, Boston, Mass. (US); Julian F. Bond, Weymouth, Mass. (US); Andrew W. Brauer, Salem, Mass. (US); Malcolm Morville, Shrewsbury, Mass. (US); Thomas J. Briner, Arlington, Mass. (US); and Ze'ev Shaked, Berkeley, Calif. (US) | ||
| Assigned to Merck Patent GmbH, Darmstadt (Germany) | ||
| Filed on Sep. 15, 2000, as Appl. No. 9/662,784. | ||
| Application 08/431184 is a division of application No. 08/300928, filed on Sep. 02, 1994, granted, now 6,019,972, filed on Feb. 01, 2000. | ||
| Application 09/662784 is a continuation of application No. 08/431184, filed on Apr. 28, 1995, granted, now 6,120,769, filed on Sep. 19, 2000. | ||
| Application 08/300928 is a continuation in part of application No. 08/006116, filed on Jan. 15, 1993, abandoned. | ||
| Application 08/006116 is a continuation in part of application No. 07/884718, filed on May 15, 1992, abandoned. | ||
| Application 07/884718 is a continuation in part of application No. 07/857311, filed on Mar. 25, 1992, abandoned. | ||
| Application 07/857311 is a continuation in part of application No. 07/807529, filed on Dec. 13, 1991, granted, now 5,547,669, filed on Aug. 20, 1996. | ||
| Application 07/807529 is a continuation in part of application No. 07/662276, abandoned, previously published as PCT/US90/06548, filed on Nov. 02, 1990. | ||
| Application 07/662276 is a continuation in part of application No. 07/431565, filed on Nov. 03, 1989, abandoned. | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 39/35 (2006.01); A61K 39/00 (2006.01); C07K 7/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 1/00 (2006.01) | ||
| U.S. Cl. 424—185.1 [424/193.1; 424/275.1; 530/300; 530/324; 530/325; 530/326; 530/327; 530/328; 530/329; 530/350; 435/69.1; 435/69.3; 435/252.3; 435/254.11; 536/23.5; 536/24.1; 514/2; 514/12] | 10 Claims |
| 1. A therapeutic composition, comprising a mixture of the following isolated polypeptides:
(a) an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:6; and
(b) an isolated polypeptide consisting of residues 14-39 of SEQ ID NO:6, or an epitope-containing portion thereof;
wherein said composition is capable of reducing an allergic response to a cat antigen in an individual sensitive to said antigen.
|