| US 7,481,781 B2 | ||
| Ultrasound therapy | ||
| Roger Kingdon Craig, Coleraine (United Kingdom); Anthony Patrick McHale, Coleraine (United Kingdom); and Ana Maria Rollan-Haro, Madrid (Spain) | ||
| Assigned to Gendel Limited, County Londonderry (United Kingdom) | ||
| Filed on May 16, 2003, as Appl. No. 10/439,470. | ||
| Application 10/439470 is a continuation in part of application No. PCT/GB01/05065, filed on Nov. 16, 2001. | ||
| Application PCT/GB01/05065 is a continuation in part of application No. 10/113173, filed on Mar. 29, 2002, granted, now 6,821,274. | ||
| Claims priority of provisional application 60/322588, filed on Sep. 14, 2001. | ||
| Claims priority of provisional application 60/279812, filed on Mar. 29, 2001. | ||
| Prior Publication US 2003/0229283 A1, Dec. 11, 2003 | ||
| Int. Cl. A61H 1/00 (2006.01) | ||
| U.S. Cl. 601—2 [606/32; 601/15] | 28 Claims |
| 1. A method of using an electric field and ultrasound in combination to ablate a nucleated cell of a multicellular organism,
comprising the steps of:
(a)(i) sensitizing the cell by exposure to the ultrasound so that the cell is rendered more susceptible to disruption by exposure
to the electric field than a cell which has not been so sensitized, and
(b)(i) exposing said sensitized cell to the electric field,
wherein the method begins with step (a)(i), and step (a)(i) is followed by step (b)(i), or
(a)(ii) sensitizing the cell by exposure to the electric field so that the cell is rendered more susceptible to disruption
by exposure to the ultrasound than a cell which has not been so sensitized, and
(b)(ii) exposing said sensitized cell to the ultrasound,
wherein the method begins with step (a)(ii), and step (a)(ii) is followed by step (b)(ii),
whereby the cell is ablated.
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