| US 7,479,535 B2 | ||
| Phosphorous-containing compounds with polymeric chains, and methods of making and using the same | ||
| Keith Branham, Pelham, Ala. (US); Mahesh V. Chaubal, Ellicott City, Md. (US); James P. English, Chelsea, Ala. (US); Donna Hall, Verbena, Ala. (US); and Zhong Zhao, Ellicott City, Md. (US) | ||
| Assigned to Guilford Pharmaceuticals, Inc., Baltimore, Md. (US) | ||
| Appl. No. 10/505,529 PCT Filed Feb. 25, 2003, PCT No. PCT/US03/05795 § 371(c)(1), (2), (4) Date Apr. 12, 2005, PCT Pub. No. WO03/080629, PCT Pub. Date Oct. 02, 2003. |
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| Claims priority of provisional application 60/359314, filed on Feb. 25, 2002. | ||
| Prior Publication US 2005/0182236 A1, Aug. 18, 2005 | ||
| Int. Cl. C08G 79/02 (2006.01); C08G 79/04 (2006.01); C08G 79/00 (2006.01) | ||
| U.S. Cl. 528—398 [528/399; 528/422; 528/425] | 20 Claims |
1. A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula:
 wherein, independently for each occurrence:
Q represents —O or —N(R3);
r represents 0 or 1, and s represents 3 or 2, such that r+s=3;
R1 represents a polymeric chain;
R2 represents —H, alkyl, cycloalkyl, —O-alkyl, —O-cycloalkyl, cycloalkenyl, —O-cycloalkenyl, aryl, —O-aryl, heterocycle, —O-heterocycle,
polycycle, —O-polycycle, or —N(R4)R5;
R3 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle, or polycycle;
R4 and R5, each independently, represent a hydrogen, an alkyl, an alkenyl, —(CH2)m—R6, or R4 and R5, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about
8 atoms in the ring structure;
m represents an integer from 0-10; and
R6 represents —H, alkyl, cycloakyl, —O-alkyl, —O-cycloalkyl, cycloalkenyl, —O-cycloalkenyl, aryl, —O-aryl, heterocycle, —O-heterocycle,
polycycle or —O-polycycle.
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