US 7,479,254 B2
Application using non-covalent bond between a cucurbituril derivative and a ligand
Kimoon Kim, Pohang (Korea, Republic of); Kangkyun Baek, Pohang (Korea, Republic of); Jeeyeon Kim, Pohang (Korea, Republic of); Iiha Hwang, Pohang (Korea, Republic of); Young Ho Ko, Pohang (Korea, Republic of); Narayanan Selvapalam, Pohang (Korea, Republic of); Erumaipatty R. Nagarajan, Pohang (Korea, Republic of); and Kyeng Min Park, Pohang (Korea, Republic of)
Assigned to Postech Foundation, Pohang (Korea, Republic of); and Postech Academy-Industry Foundation, Pohang (Korea, Republic of)
Filed on Apr. 20, 2006, as Appl. No. 11/407,143.
Claims priority of application No. 10-2005-0099379 (KR), filed on Oct. 20, 2005; application No. 10-2005-0108312 (KR), filed on Nov. 12, 2005; application No. 10-2006-0000891 (KR), filed on Jan. 04, 2006; and application No. 10-2006-0018434 (KR), filed on Feb. 24, 2006.
Prior Publication US 2007/0092867 A1, Apr. 26, 2007
Int. Cl. B01L 3/00 (2006.01); A61K 9/36 (2006.01); A61K 45/00 (2006.01); C12Q 1/68 (2006.01); G01N 15/06 (2006.01); G01N 33/53 (2006.01)
U.S. Cl. 422—61  [422/68.1; 424/486; 424/489; 424/278.1; 424/280; 435/6; 435/7.1; 435/7.2] 12 Claims
OG exemplary drawing
 
1. A kit comprising:
a first component that is a compound of formula (1) below bound to a first material; and
a second component that is a ligand bound to a second material,
wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and
the ligand can non-covalently bind to the compound of formula (1) below, has at least one amine group, and is selected from the group consisting of a C1-C20 alkyl group; a C2-C20 alkenyl group; a C2-C20 alkynyl group; a C1-C20 alkoxy group; a C1-C20 aminoalkyl group; a C4-C20 cycloalkyl group; a C4-C7 heteroarylcyclo group; a C6-C20 aryl group; a C5-C20 heteroaryl group; a C1-C20 alkylsilyl group; a C6-C20 aryl group; a C5-C20 heteroaryl group; adamantane having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; ferrocene or metallocene having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; carborane having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; fullerene having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; cyclam or crown ether having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; an oxygen-protected amino acid having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; peptide having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; alkaloid having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; cisplatin having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; oligonucleotide having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; rhodamine having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group; and a nanoparticle having a substituted or non-substituted C1-C20 alkyl group, C6-C20 aryl group or C5-C20 heteroaryl group,

OG Complex Work Unit Drawing
where n is an integer from 6 to 10;
X is O, S or NH;
each of A1 and A2 is independently H, OR, SR, or NHR, and A1 and A2 are not simultaneously H,
where R is selected from the group consisting of H; a substituted or non-substituted C1-C30 alkyl group; a substituted or non-substituted C2-C30 alkenyl group; a substituted or non-substituted C2-C30 alkynyl group; a substituted or non-substituted C2-C30 carbonylalkyl group; a substituted or non-substituted C1-C30 thioalkyl group; a substituted or non-substituted C1-C30 alkylthiol group; a substituted or non-substituted C1-C30 hydroxyalkyl group; a substituted or non-substituted C1-C30 alkylsilyl group; a substituted or non-substituted C1-C30 aminoalkyl group; a substituted or non-substituted C1-C30 aminoalkylthioalkyl group; a substituted or non-substituted C5-C30 cycloalkyl group; a substituted or non-substituted C2-C30 heterocycloalkyl group; a substituted or non-substituted C6-C30 aryl group; a substituted or non-substituted C6-C30 arylalkyl group; a substituted or non-substituted C4-C30 heteroaryl group; and a substituted or non-substituted C4-C30 heteroarylalkyl group.