| US 7,476,674 B2 | ||
| Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics | ||
| Frederic Galli, Vaucresson (France); Odile Leclerc, Massy (France); Alistair Lochead, Charenton le Pont (France); and Julien Vache, Paris (France) | ||
| Assigned to Sanofi-Aventis, Paris (France) | ||
| Filed on Feb. 11, 2008, as Appl. No. 12/29,008. | ||
| Application 12/029008 is a continuation of application No. PCT/FR2006/001911, filed on Aug. 07, 2006. | ||
| Claims priority of application No. 0508594 (FR), filed on Aug. 18, 2005. | ||
| Prior Publication US 2008/0176855 A1, Jul. 24, 2008 | ||
| Int. Cl. C07D 403/04 (2006.01); C07D 403/14 (2006.01); A61K 31/501 (2006.01) | ||
| U.S. Cl. 514—252.04 [544/238] | 16 Claims |
1. A compound of formula (I):
 R is
either a hydrogen or halogen atom;
or a phenyl group optionally substituted with one or more halogen atoms, or with one or more groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, di(C1-C3)alkylamino, trifluoromethyl, trifluoromethoxy, cyano, hydroxyl, acetyl or methylenedioxy groups;
or a group selected from pyridinyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl,
thienyl, furyl, isoxazolyl, isothiazolyl, pyrrolyl and naphthyl, it being possible for this group to be optionally substituted
with one or more groups selected from halogen atoms, and (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, hydroxyl, amino, (C1-C6)alkylamino or di(C1-C6)alkylamino groups;
or an acid addition salt thereof.
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