m is 1;

n is 1;

a, b, c independently are a single or a double bond;

X is a covalent bond or a bivalent C_1-6alkanediyl radical wherein one or more —CH₂— groups may be optionally replaced with —O—, —S—, —C(═O)— or NR⁷—; wherein:

R⁷ is selected from the group consisting of hydrogen, alkyl, Ar, Ar-alkyl, Het, Het-alkyl, hydroxyalkyl, alkyloxy, alkyloxyalkyl, alkyloxyalkyloxyalkyl, aminoalkyl, mono- or dialkylaminoalkyl, formyl, alkylcarbonylaminoalkyl, alkylcarbonyloxyalkyl, alkyloxycarbonyl, alkyloxycarbonylalkyl, alkylaminocarbonyl, alkylaminocarbonylalkyl, hydroxyalkyloxyalkyl, aminocarbonyl, aminocarbonylalkyl, alkyloxycarbonyl, alkylcarbonyl and alkylcarbonyloxyalkyloxyalkyl;

Y is —CH₂—CH₂—;

Z is N, in which case a is a double bond and b is a single bond; or is N—R⁷ in which case a is a single bond and R⁷ is defined as above;

R¹, R² independently are selected from the group consisting of hydrogen, hydroxy, alkyl, alkyloxy, Ar, Ar-alkyl, di(Ar—)alkyl, Het and Het-alkyl;

-A-B— independently is selected from the group consisting of a bivalent radical of formula

-E-CR⁸═CR⁸—  (a-1);

—CR⁸═CR⁸-E-  (a-2);

and

—CR⁸═CR⁸—CR⁸═CR⁸—  (a-3);

wherein:

R⁸ each independently is selected from the group consisting of hydrogen, halo, hydroxy, alkyl or alkyloxy;

E is selected from the group consisting of a bivalent radical of formula —O—, —S— and —NR⁷— wherein R⁷ is defined as above;

—C-D- independently is selected from the group consisting of a bivalent radical of formula

—CR⁸═CR⁸—CR⁸═CR⁸—  (b-1);

—N═CR⁸—CR⁸═CR⁸—  (b-2);

—CR⁸═N—CR⁸═CR⁸—  (b3);

—CR⁸═CR⁸—N═CR⁸—  (b-4);

and

—CR⁸═CR⁸—CR⁸═N—  (b-5);

wherein R⁸ is defined as above;

R³ is selected from the group consisting of hydrogen, halo, hydroxy, alkyl, oxo, alkyloxy, Ar, Ar-alkyl, di(Ar—)alkyl, Het and Het-alkyl;

R⁴ is selected from the group consisting of hydrogen, alkyl, amino, alkylamino, Ar-amino, Het-amino, Het-alkylamino, alkylcarbonylamino, Ar-carbonylamino, Het-carbonylamino, alkylaminocarbonylamino, Ar-aminocarbonylamino, Het-aminocarbonylamino, alkyloxyalkylamino, Ar-oxyalkylamino or Het-oxyalkylamino;

R⁵ is hydrogen and alkyl;

or R⁴ and R⁵ together may form a radical of Formula

-M-CR⁹═CR¹⁰—  (c-1);

—CR¹⁰═CR⁹-M-  (c-2);

-M-CR⁸R⁸—CR⁸R⁸—  (c-3);

—CR⁸R⁸—CR⁸R⁸-M-  (c-4);

—CR⁸═N—NR⁷—  (c-5);

—NR⁷—N═CR⁸—  (c-6);

—CR⁹═CR¹⁰—CR⁹═CR¹⁰—  (c-7);

—CR⁸R⁸—CR⁸R⁸—CR⁸R⁸-M-  (c-8);

-M—CR⁸R⁸—CR⁸R⁸—CR⁸R⁸—  (c-9);

—CR⁸R⁸—CR⁸═N—NR⁷—  (c-10);

—NR⁷—N═CR⁸—CR⁸R⁸—  (c-11);

═N—CR⁹═CR¹⁰—  (c-12);

or

—CR⁹═CR¹⁰—N═  (c-13);

wherein:

R⁷ and R⁸ are defined as above;

R⁹, R¹⁰ independently are selected from the group consisting of hydrogen, alkyl, halo and haloalkyl; or R⁹ and R¹⁰ together may form a bivalent radical of formula —CR⁸═CR⁸—CR⁸═CR⁸— wherein R⁸ is defined as above; and

M is selected from the group consisting of a bivalent radical of formula —CH₂—, —O—, —S— and —NR⁷— wherein R⁷ is defined as above;

Ar is a homocycle selected from the group consisting of naphthyl and phenyl, each optionally substituted with 1, 2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitro, amino, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, carboxyl, alkyloxycarbonyl, aminocarbonyl and mono- or dialkylaminocarbonyl;

Het is a monocyclic heterocycle selected from the group consisting of pyrrolyl, pyrazolyl, imidazolyl, furyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected from the group of quinolinyl, quinoxalinyl, indolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuryl, isoindolyl and benzothienyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with one or more halo, oxo, hydroxy, alkyl and alkyloxy radicals;

alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; wherein each carbon atom can be optionally substituted with one or more halo, hydroxy, alkyloxy or oxo radicals;

halo is a substituent selected from the group consisting of fluoro, chloro, bromo and iodo; and

haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more carbonatoms are substituted with one or more halo-atoms.