| US 7,474,906 B2 | ||
| Method for dye injection for the transcutaneous measurement of cardiac output | ||
| Eduardo H. Rubinstein, Los Angeles, Calif. (US); Daniel P. Holschneider, Los Angeles, Calif. (US); and Jean-Michel I. Maarek, Rancho Palos Verdes, Calif. (US) | ||
| Assigned to Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California, Los Angeles, Calif. (US) | ||
| Filed on May 03, 2007, as Appl. No. 11/744,147. | ||
| Application 11/744147 is a continuation in part of application No. 10/847480, filed on May 17, 2004. | ||
| Application 10/847480 is a continuation of application No. 10/153387, filed on May 21, 2002, granted, now 6,757,554, filed on Jun. 29, 2004. | ||
| Claims priority of provisional application 60/747401, filed on May 16, 2006. | ||
| Claims priority of provisional application 60/292580, filed on May 22, 2001. | ||
| Prior Publication US 2008/0004511 A1, Jan. 03, 2008 | ||
| Int. Cl. A61B 5/00 (2006.01); A61B 5/02 (2006.01) | ||
| U.S. Cl. 600—317 [600/481] | 13 Claims |
| 1. A method of dye injection for measuring cardiac output of the cardiovascular system of a subject comprising:
a) preparing a predetermined quantity of a dye solution that can be detected optically by fluorescence when administered into
the cardiovascular system of the subject;
b) preparing a predetermined quantity of a physiologic solution to be administered following the dye solution;
c) administering the dye solution as a bolus to the cardiovascular system of the subject within a predetermined period; and
d) administering the physiologic solution as a bolus to the cardiovascular system within a predetermined period subsequent
to administration of the dye solution;
e) calculating the cardiac output of the cardiovascular system based on a proportionality factor that exist between a concentration
of the administered dye solution in the cardiovascular system and fluorescence that is transcutaneously detected from the
dye solution in the cardiovascular system.
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