US 7,473,527 B2
Compounds promoting delivery of genes
Eric J. Sorscher, Birmingham, Ala. (US)
Assigned to The UAB Research Foundation, Birmingham, Ala. (US)
Appl. No. 10/520,377
PCT Filed Jul. 02, 2003, PCT No. PCT/US03/20732
§ 371(c)(1), (2), (4) Date May 19, 2005,
PCT Pub. No. WO2004/005464, PCT Pub. Date Jan. 15, 2004.
Claims priority of provisional application 60/393266, filed on Jul. 02, 2002.
Prior Publication US 2006/0233754 A1, Oct. 19, 2006
Int. Cl. C12Q 1/68 (2006.01)
U.S. Cl. 435—6  [435/455; 424/450] 32 Claims
 
1. A kit for activating gene transfer, said kit comprising a gene transfer activating compound packaged in a suitable container together with instructions for use to activate gene transfer wherein said gene transfer compound is selected from the group consisting of:

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing
wherein Q is nitrogen or oxygen, wherein each occurrence of R1 independently is H, CH3, CH2CH3 or a nullity, wherein R2 is C1-C18 alleyl, C2-C18 ether, C2-C18 thioether, C2-C18 secondary or tertiary amine,
wherein A is

OG Complex Work Unit Drawing
wherein R3 is H, C1-C6 alkyl, or a heteroatom substituted C1-C6 alkyl where the heteroatom is oxygen, nitrogen, or sulfur, wherein R4 is C2-C6 amide; or ═N—R5 where R5 is C7-C12 aryloxyl, C1-C6 hydronyl, carbonyl, carboxyl, or acyl, imidazyl, pyrazyl, thiazyl, or oxazyl, wherein X is H, F, Cl or Br, wherein Z is oxygen or sulfur.