From: Patrea Pabst [e-mail address redacted] Sent: Monday, April 21, 2014 1:28 PM To: myriad-mayo_2014 Cc: Partners Subject: Comments On March 3, 2014, the United States Patent Office issued new guidelines on what it considers to be patent-eligible subject matter under 35 U.S.C. 101 in view of recent Supreme Court cases. The implications are staggering. The Patent Office has decided that combinations of naturally occurring materials are not patent-eligible subject matter unless they meet a structural and functional test, and, in contrast to prior case law, places the burden on the applicant to show that the claimed subject matter meets these tests. The guidelines are now being implemented and office actions are issuing that call into question the patentability of many of the claims in our pending cases and in THOUSANDS of issued patents. Just the negative office actions questioning the patentability of the claimed subject matter could result in loss of licensing opportunities, sponsored research and investments. We do not agree that the Supreme Court intended to invalidate thousands of patents on the basis of patent-eligibility, nor that the Patent Office has the authority to rewrite a U.S. statute, 35 U.S.C. 101, through issuance of guidelines not subject to review by the American people and their congressional representatives. We have urged our clients to immediately contact their congressional representatives and ask that the Patent Office be encouraged to withdraw these guidelines and reassess them in view of the enormous negative effect these guidelines will have on thousands of previously issued patents as well as pending applications, which in turn is likely to inhibit licensing, investment and sponsored research. Patrea L. Pabst Pabst Patent Group LLP 1545 Peachtree St NE Suite 320 Atlanta, GA 30309 [e-mail address redacted] 404-879-2151